Table 3.

The enrichment analysis result of NetGen on cervical carcinogenesis dataset

Rank	GO ID	Description	p-value
1	GO:0006271	DNA strand elongation involved in DNA replication	3.42e-11
2	GO:0090224	regulation of spindle organization	1.78e-3
3	GO:0001927	exocyst assembly	6.43e-3
4	GO:0038016	insulin receptor internalization	6.43e-3
5	GO:0070676	intralumenal vesicle formation	6.43e-3
6	GO:0086042	cardiac muscle cell-cardiac muscle cell adhesion	6.43e-3
7	GO:0014738	regulation of muscle hyperplasia	1.28e-2
8	GO:2000393	negative regulation of lamellipodium morphogenesis	1.28e-2
9	GO:0010993	regulation of ubiquitin homeostasis	1.28e-2
10	GO:0006050	mannosamine metabolic process	1.28e-2
11	GO:0046602	regulation of mitotic centrosome separation	1.92e-2
12	GO:0072708	response to sorbitol	1.92e-2
13	GO:0001992	regulation of systemic arterial blood pressure by vasopressin	1.92e-2
14	GO:1902498	regulation of protein autoubiquitination	1.92e-2
15	GO:0048388	endosomal lumen acidification	1.92e-2
16	GO:0048280	vesicle fusion with Golgi apparatus	2.55e-2
17	GO:0097264	self proteolysis	3.18e-2
18	GO:0045329	carnitine biosynthetic process	3.18e-2
19	GO:0051382	kinetochore assembly	7.45e-2
20	GO:0000741	karyogamy	1
21	GO:2000656	regulation of apolipoprotein binding	1
22	GO:0032848	negative regulation of cellular pH reduction	1
23	GO:0090158	endoplasmic reticulum membrane organization	1

Best parameter setting: p ₁=0.5, p ₂=0.05, q=0.001. Term combination p=1.10e-37

An appropriate parameter combination identified via a mixed parameter selection strategy was shown at the bottom of the table. The Fisher’s exact test p-values for single term and term combination were listed. The GO terms in bold were particularly identified by NetGen