Figure 2.

Bronchopulmonary dysplasia and pulmonary hypertension (PH). (A–C) Altered angiogenesis during lung development in the presence of perinatal and postnatal factors leads to pulmonary hypertension in BPD; (D) smooth muscle actin (SMA) staining demonstrating increasing thickness of the pulmonary arterioles following neonatal O₂ exposure (arrows—Figure 2D); (E) high power magnification (400×) illustrating smooth muscle thickness of the pulmonary vessel wall. SGA: small for gestational age. ROM: rupture of membranes.