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. 2017 Jul 21;4(3):64. doi: 10.3390/bioengineering4030064

Figure 3.

Figure 3

Tumor angiogenesis on a chip. (A) Human glioblastoma multiforme cells, (U87MG) were used to induce angiogenic sprouting. Fluorescence image shows angiogenic sprouts grown for 2 and 4 days under co-culture with U87MG cancer cells and human umbilical vein endothelial cells (HUVEC) (i, ii) [32]. Scale bar: 50 μm; (B) Pre-vascularized tumor (PVT) spheroid model. PVT spheroid model were introduced breast cancer (MCF10A, MDA-MB-231), Lung cancer (A549) and colon cancer (SW620). Representative fluorescence images of PVT spheroid model shows robust angiogenic sprouting. Various PVT spheroid showed different angiogneic sprouting behavior. Intravasation events were only observed for SW620 cancer cells [37]. Scale bar: 100 μm. Reproduced with permission.