Table 9.

Description of model parameters for the mathematical framework.

Parameters	Interpretation
$K_R$	Number of fractions
$K_C$	Number of chemotherapy cycles
$d_R$ (Gy)	Radiation dose per fraction
$d_C$ (mg/m2)	Chemotherapy dose per cycle
$\lambda$ (per day)	Proliferation rate of normal cells
$r$	Relative growth of premalignant cells
$r\lambda$	Proliferation rate of premalignant cells
${\gamma }_R$ (per Gy)	Mutation rate induced by radiation
${\gamma }_C$ (per chemotherapy dose)	Mutation rate induced by chemotherapy
${\alpha }_R$ (per Gy)	Cell kill due to radiotherapy
${\alpha }_d$ (per unit time)	Decay rate of chemotherapy drug
${\alpha }_C$ (per chemotherapy dose)	Cell kill due to chemotherapy