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Members of four generations of clinical steroidal (c,f) and nonsteroidal (a,b,d,e) aromatase (CYP19A1) inhibitors. First generation: aminoglutethimide (a, Cytadren, Novartis).99−101 Second generation: Fadrozole (b, Afema, Novartis),99−101 and Formestane (c, Lentaron, Novartis).14 Third generation: Anastrozol (d, Arimidex, AstraZeneca),102 Letrozole (e, Femara, Novartis),103−105 and Exemestane (f, Aromasine, Pfizer).103
