Fig. 2.

Effects of non-mucoadhesive or mucoadhesive formulations containing BP/CL on small intestinal histological damage of mucositis-bearing mice induced by 5-FU. Formulation doses or blank formulation were administered orally (gavage) to mice over 6 days, while doses of 5-FU (200 mg/kg) were administered intraperitoneally from 4th to 6th day. On day 7, animals (n = 5 mice/group) were euthanized and the small intestine of each mice was collected for morphometry analysis. Photomicrographs are representative of each treatment group.