Fig. 3.

Effects of the mucoadhesive formulation at 125 mg/kg + BP 15 mg/kg CL dose on the variation of corporal mass of mucositis-bearing mice induced by 5-FU. Formulation doses or blank formulation were administered orally (gavage) to mice over 6 days, while doses of 5-FU (200 mg/kg) were administered intraperitoneally from 4th to 6th day. Mice were weighed throughout 7 days of the experiment to obtain the variation in body mass (%). Each point presents mean ± SD of animals (n = 5). (^*p < 0.05 and ^***p < 0.001 vs. control; ^#p < 0.05 and ^###p < 0.001 vs. 5-FU. Two-way ANOVA and Bonferroni test).