Table 1.
Effect of aqueous bark extract of Quillaja saponaria at 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg po and indomethacin as compared to carragenan control in carragenan induced paw edema model using vernier callipers.
| Groups n = 5 (in mm) |
0 hr | 30 min | 1 hr | 2 hr | 3 hr | 4 hr |
|---|---|---|---|---|---|---|
| Carragenan (1% w/v) | 1.8 ± 0.05 | 3.34 ± 0.06 | 3.9 ± 0.03 | 3.99 ± 0.05 | 3.95 ± 0.06 | 3.99 ± 0.02 |
| Carragenan + Indomethacin (10 mg/kg bw) | 1.8 ± 0.05 | 3.0 ± 0.05 | 2.96 ± 0.07 (24.1%) |
2.25 ± 0.04 (43.6%) |
2.2 ± 0.06a (44.3%) |
1.8 ± 0.06a (55%) |
| Carragenan + Quillaja saponaria 1 mg/kg, bw |
1.85 ± 0.26 | 3.4 ± 0.05 | 3.5 ± 0.12 (10.25%) |
3.30 ± 0.15 (17.29%) |
3.25 ± 0.05a (17.72%) |
3.2 ± 0.01a (19.79%) |
| Carragenan + Quillaja saponaria 5 mg/kg bw | 1.85 ± 0.12 | 2.8 ± 0.01 | 3.3 ± 0.1 (15.38%) |
3.25 ± 0.25 (18.54%) |
3.2 ± 0.01a (18.98%) |
3.0 ± 0.06a (24.8%) |
| Carragenan + Quillaja saponaria 10 mg/kg bw | 1.8 ± 0.06 | 2.9 ± 0.05 | 3.25 ± 0.02 (16.66%) |
3.28 ± 0.12 (17.79%) |
3.05 ± 0.02a (22.78%) |
2.77 ± 0.05a (30.57%) |
| Carragenan + Quillaja saponaria 20 mg/kg bw | 1.85 ± 0.01 | 2.88 ± 0.02 | 3.2 ± 0.01 (17.94%) |
3.25 ± 0.15 (18.54%) |
3.0 ± 0.01a (24.05%) |
2.4 ± 0.01a (40%) |
Values are expressed as mean ± SD.
a
P < 0.05-significant compared to carragenan treated group.