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. 2017 Sep 26;19:211. doi: 10.1186/s13075-017-1402-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — HM71224 limits renal impairment. Serum blood urea nitrogen (BUN) and creatinine (CRE) were measured at the end of the study. Treatment of MRL/lpr mice with HM71224 reduced BUN (a) but increased CRE was not observed at 28 weeks of age, even in vehicle-treated mice (b). Treatment of NZB/W F1 mice with HM71224 resulted in a significant decrease in BUN (c) and CRE (d) at 40 weeks of age. Data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 versus vehicle control determined by analysis of variance (BUN and CRE in c and d) and the Kruskal–Wallis test (BUN in a)