Table 3.
Rat specific cholestasis gene signature. The top 100 genes associated with rat cholestasis, as derived by a boosting procedure with the elastic net approach. Genes were selected by comparing compounds (all known cholestatic in patients) from the two training sets in Table 2.
| Codelink | Accession # | Rat gene |
|---|---|---|
| GE1266870 | BE115850 | Gstcd |
| GE20245 | NM_013215 | Akr7a3 |
| GE1298481 | BM391646 | Nars |
| GE21882 | NM_031588 | Nrg1 |
| GE14709 | AI230228 | Psat1 |
| GE1147805 | CB578405 | Zfp57 |
| GE12632 | AI704698 | Tubb2c |
| GE16026 | AW252110 | Rexo2 |
| GE1130267 | BI296275 | Mmd2 |
| GE20928 | NM_031828 | Kcnma1 |
| GE16596 | AW915559 | Pprc1 |
| GE20102 | NM_012991 | Npap60 |
| GE1206415 | BI297088 | Golt1b |
| GE15377 | BI296275 | Mmd2 |
| GE15995 | AW251324 | Mthfd2-201 |
| GE18028 | BI273851 | Hmgn1 |
| GE1287407 | BI282107 | Pbdc1 |
| GE1262741 | BE110134 | Similar to ATPase inhibitory factor 1 |
| GE1259381 | NM_138515 | Cyp2d4v1 |
| GE19894 | NM_012674 | Spink1 |
| GE1173529 | CA507720 | Pgs1 |
| GE16306 | BQ206238 | Ankhd1 |
| GE1168184 | NM_031318 | Tctex1 |
| GE13574 | NM_053800 | Txn1 |
| GE1185733 | BF552430 | NosipGE1116501 BF565830 |
| GE17633 | BE110630 | Fam98a |
| GE19200 | BF550623 | Cad |
| GE1128152 | AF507943 | GTPase Ran |
| GE1150923 | BF398625 | Yars |
| GE17038 | H33863 | Mrps27 |
| GE1106781 | BU760106 | Tubb6 |
| GE20964 | NM_133539 | Mrpl17 |
| GE1287274 | BF405056 | |
| GE1249888 | BG380189 | Map3k6 |
| GE16626 | BI302502 | Fkbp11 |
| GE1167706 | NM_173102 | Tubb5 |
| GE1261576 | BF416050 | |
| GE20940 | NM_024390 | Hpgd |
| GE18776 | BF406522 | Cdr2 |
| GE17115 | BE096047 | Ran |
| GE1174448 | BC062045 | similar to lipase, member H |
| GE1181134 | BM389611 | |
| GE19529 | NM_134449 | Prkcdbp |
| GE1101245 | BF401159 | |
| GE15329 | AI412180 | Gsr |
| GE1170908 | BE096969 | Slc35e3 |
| GE1195574 | BG373486 | Lsm4 |
| GE20274 | NM_017014 | Gstm1 |
| GE14242 | BI291621 | Coq6 |
| GE1305121 | AI235475 | EST232037 |
| GE12903 | AA946350 | Gnai1 |
| GE1206195 | BI274696 | similar to Fam48a protein |
| GE19392 | BG374448 | TLOAEA57YJ04 |
| GE1166787 | BM391708 | |
| GE1291343 | BQ202678 | Xpo1 |
| GE1219528 | BF562712 | Trmt10a |
| GE1135723 | BM384823 | Ppp1r3b |
| GE1237072 | BQ202004 | Gstm4 |
| GE1277644 | NM_031039 | Gpt1 |
| GE1236134 | AW433632 | |
| GE22230 | NM_053962 | Sds |
| GE17670 | BE113943 | Tigar |
| GE1216317 | BU759545 | Trmt10a |
| GE1210818 | NM_024148 | Apex1 |
| GE1125325 | X78847 | GstYc2 |
| GE1262042 | BI296358 | Apmap |
| GE1100230 | NM_138831 | Slc16a10 |
| GE12644 | NM_175707 | Ppil3 |
| GE1297200 | BF412090 | Xkr8 |
| GE1168155 | BF288225 | EST452816 |
| GE17771 | BE113165 | Nek6 |
| GE1205310 | NM_133558 | Cml1 |
| GE22027 | NM_053902 | Kynu |
| GE1197342 | BQ194442 | Krt23 |
| GE15769 | AA956532 | |
| GE14364 | BG379780 | Mcee |
| GE20988 | NM_031051 | Mif |
| GE1158473 | BF521726 | Srxn1 |
| GE16476 | BM388044 | |
| GE16012 | H35647 | Tnfrsf12a |
| GE18057 | BF281848 | Mthfd1l |
| GE1284234 | AI169152 | Mafb |
| GE1130388 | AI137440 | |
| GE1167776 | BF420077 | |
| GE16853 | AW918024 | Nif3l1 |
| GE1119096 | CA505586 | |
| GE1274350 | BF388173 | Ptprd |
| GE1201399 | BF415461 | |
| GE15155 | AI409108 | Nup205_predicted |
| GE13570 | NM_053439 | Ran |
| GE15126 | AI408727 | Lurap1l |
| GE1296800 | NM_184048 | Taf9 |
| GE16570 | AW915407 | EST346711 |
| GE12527 | BM384489 | Hmgn3 |
| GE1228263 | BE098757 | |
| GE20373 | NM_017147 | Cfl1 |
| GE1236758 | NM_198771 | Fam3c |
| GE19575 | NM_053962 | Sds |
| GE1210173 | BF394858 |