Table 2.

Summary of in vitro micronucleus assay results for CGTase and sodium sulfate.

Dose (μg/mL)	Micronucleus frequency (%)		Apoptotic/necrotic cells (%)		Relative survival (%)	Dose (μg/mL)	Micronucleus frequency (%)		Apoptotic/necrotic cells (%)		Relative survival (%)
	Mean	Fold change	Mean	Fold change			Mean	Fold change	Mean	Fold change
CGTase
4 h with S9						24 h without S9
0	0.84 ± 0.2	1.0	1.6 ± 0.1	1.0	100	0	0.61 ± 0.1	1.0	1.6 ± 0.1	1.0	100
1000	0.66 ± 0.1	0.8	3.5 ± 0.1	2.2	106	1000	0.66 ± 0.0	1.1	3.2 ± 0.2	2.1	101
2000	1.06 ± 0.5	1.3	3.9 ± 1.8	2.4	75	2000	0.63 ± 0.1	1.0	4.3 ± 0.9	2.8	89
3000	0.83 ± 0.3	1.0	4.8 ± 1.7	3.0	74	3000	0.61 ± 0.0	1.0	4.6 ± 0.4	3.0	82
4000	0.82 ± 0.2	1.0	8.2 ± 3.5	5.2	78	4000	0.66 ± 0.1	1.1	4.0 ± 0.3	2.6	72
5000	0.80 ± 0.2	0.9	6.1 ± 1.1	3.9	65	5000	0.82 ± 0.2	1.3	4.7 ± 0.7	3.1	73
6000	0.89 ± 0.2	1.1	6.0 ± 0.8	3.8	62	6000	0.68 ± 0.1	1.1	5.8 ± 1.5	3.8	73
CP	3.53 ± 0.1	4.2	6.0 ± 2.0	3.8	52	VIN	9.81 ± 1.4	20.6	4.2 ± 0.1	3.0	57
Sodium sulfate
4 h with S9						24 h without S9
0	0.93 ± 0.1	1.0	2.4 ± 0.2	1.0	100	0	0.76 ± 0.4	1.0	2.3 ± 0.4	1.0	100
20.6	0.93 ± 0.0	1.0	1.9 ± 0.1	0.8	103	20.6	0.56 ± 0.1	0.7	2.0 ± 0.2	0.9	105
61.7	0.84 ± 0.1	0.9	2.2 ± 0.3	0.9	103	61.7	0.57 ± 0.1	0.8	2.0 ± 0.1	0.9	112
185	0.78 ± 0.0	0.8	2.1 ± 0.2	0.9	106	185	0.54 ± 0.1	0.7	2.0 ± 0.2	0.9	98
556	1.01 ± 0.1	1.1	2.0 ± 0.2	0.8	101	556	0.58 ± 0.1	0.8	1.8 ± 0.3	0.8	104
1667	0.84 ± 0.0	0.9	2.0 ± 0.2	0.9	85	1667	0.57 ± 0.1	0.8	2.0 ± 0.2	0.9	87
5000	1.18 ± 0.0	1.3	2.8 ± 0.1	1.2	72	5000	0.53 ± 0.0	0.7	2.5 ± 0.3	1.1	86
CP	7.49 ± 1.1	7.6	10.6 ± 2.5	3.8	37	VIN	6.25 ± 0.7	13.0	7.4 ± 0.5	4.1	51

CP = cyclophosphamide; VIN = vinblastine.