Table 5a.
Hemogram data from rats exposed to CGTase for 90 days.
| Dose level (mg/kg/day) | Sex | WBC (1000/μL) ± SD |
RBC (1000000/μL) ± SD | HGB (g/dL) ± SD |
HCT (%) ± SD |
MCV (Fl) ± SD |
MCH (pg) ± SD |
MCHC (g/dL) ± SD |
|---|---|---|---|---|---|---|---|---|
| 0 | M | 12.69 ± 2.60 (10)a | 10.37 ± 0.90 (10) | 21.7 ± 1.7 (10) | 60.4 ± 6.0 (10) | 58.1 ± 1.3 (10) | 21.0 ± 0.9 (10) | 36.1 ± 1.5 (10) |
| 250 | M | 12.22 ± 2.57 (8) | 9.88 ± 0.62 (8) |
21.0 ± 1.3 (8) | 57.5 ± 2.9 (8) | 58.3 ± 1.7 (8) | 21.3 ± 1.0 (8) | 36.4 ± 0.8 (8) |
| 500 | M | 13.71 ± 2.49 (6) | 9.92 ± 0.34 (6) |
20.6 ± 1.1 (6) | 57.4 ± 3.5 (6) | 57.8 ± 2.1 (6) | 20. 8 ± 0.6 (6) | 36.0 ± 0.9 (6) |
| 1000 | M | 12.15 ± 2.06 (9) | 9.49 ± 0.46* (9) | 20.0 ±0.7* (9) |
54.9 ± 2.9* (9) | 57.9 ± 1.7 (9) | 21.1 ± 0.6 (9) | 36.4 ± 1.2 (9) |
| 0 | F | 9.24 ± 3.21 (9) | 9.05 ± 0.85 (9) |
20.2 ± 1.5 (9) | 53.2 ± 5.3 (9) | 58.7 ± 1.0 (9) | 22.3 ± 0.7 (9) | 38.0 ± 1.3 (9) |
| 250 | F | 9.16 ± 0.83 (8) | 8.94 ± 0.48 (8) |
19.6 ± 0.6 (8) | 52.0 ± 2.8 (8) | 58.2 ± 1.4 (8) | 21.9 ± 0.7 (8) | 37.6 ± 1.4 (8) |
| 500 | F | 8.80 ± 1.82 (10) | 9.27 ± 0.48 (10) | 20.1 ± 1.3 (10) | 54.1 ± 3.4 (10) | 58.4 ± 1.2 (10) | 21.7 ± 1.0 (10) | 37.2 ± 1.4 (10) |
| 1000 | F | 9.72 ± 2.46 (9) | 9.36 ± 0.60 (9) |
20.0 ± 0.9 (9) | 54.4 ± 3.2 (9) | 58.1 ± 1.0 (9) | 21.4 ± 0.8* (9) | 36.7 ± 1.2 (9) |
SD = standard deviation; WBC = white blood cells; RBC = red blood cells; HGB = hemoglobin; HCT = hematocrit; MCV = mean corpuscular volume; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration.
a
Number of samples.
*
Statistically significant when compared to the concurrent control, p < 0.05.