Table 5b.
Platelet and absolute white blood cell differential counts from rats exposed to CGTase for 90 days.
| Dose Level (mg/kg/day) | Sex | Platelets (1000/μL) ± SD | Lymphocytes (1000/μL) ± SD | Monocytes (1000/μL) ± SD | Eosinophils (1000/μL) ± SD | Basophils (1000/μL) ± SD | Leukocytes (1000/μL) ± SD | Neutrophils (1000/μL) ± SD |
|---|---|---|---|---|---|---|---|---|
| 0 | M | 720 ± 210 (10)a | 10.35 ± 2.11 (10) | 0.42 ± 0.15 (10) | 0.16 ± 0.06 (10) | 0.23 ± 0.13 (10) | 0.14 ± 0.04 (10) | 1.41 ± 0.28 (10) |
| 250 | M | 754 ± 211 (8) | 9.58 ± 2.29 (8) |
0.39 ± 0.14 (8) | 0.32 ± 0.35 (8) | 0.17 ± 0.06 (8) | 0.12 ± 0.05 (8) |
1.65 ± 0.36 (8) |
| 500 | M | 771 ± 178 (6) | 10.60 ± 2.02 (6) | 0.44 ± 0.10 (6) | 0.21 ± 0.11 (6) | 0.19 ± 0.04 (6) | 0.13 ± 0.05 (6) |
2.14 ± 0.73* (6) |
| 1000 | M | 818 ± 122 (9) | 9.81 ± 1.79 (9) |
0.41 ± 0.11 (9) | 0.19 ± 0.10 (9) | 0.15 ± 0.06 (9) | 0.15 ± 0.04 (9) |
1.44 ± 0.29 (9) |
| 0 | F | 804 ± 273 (9) | 7.45 ± 2.99 (9) |
0.28 ± 0.10 (9) | 0.20 ± 0.17 (9) | 0.13 ± 0.08 (9) | 0.10 ± 0.05 (9) |
1.08 ± 0.31 (9) |
| 250 | F | 858 ± 104 (8) | 7.56 ± 0.62 (8) |
0.26 ± 0.06 (8) | 0.15 ± 0.08 (8) | 0.11 ± 0.02 (8) | 0.11 ± 0.02 (8) |
0.97 ± 0.32 (8) |
| 500 | F | 885 ± 163 (10) | 7.36 ± 1.77 (10) | 0.32 ± 0.14 (10) | 0.14 ± 0.07 (10) | 0.10 ± 0.04 (10) | 0.09 ± 0.04 (10) | 1.09 ± 0.34 (10) |
| 1000 | F | 686 ± 210 (9) | 7.76 ± 2.19 (9) |
0.34 ± 0.17 (9) | 0.22 ± 0.16 (9) | 0.12 ± 0.05 (9) | 0.12 ± 0.06 (9) |
1.18 ± 0.28 (9) |
SD = Standard deviation.
a
Number of samples.
*
Statistically significant when compared to the concurrent control, p < 0.05.