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. 2016 Mar 7;3:381–392. doi: 10.1016/j.toxrep.2016.03.002

Table 7.

Coagulation tests and hormone analyses.

Dose level (mg/kg/day) Sex PT (seconds) ± SD APTT (seconds) ± SD Total T3 (ng/dL) ± SD Total T4 (μg/dL) ± SD Total TSH (ng/mL) ± SD
0 M 11.9 ± 0.7 (10)a 21.9 ± 3.9 (10) 136.7 ± 38.9 (10) 4.5 ± 1.3 (10) 14.7 ± 8.7 (10.0)
250 M 12.0 ± 1.2 (9) 20.6 ± 2.9 (9) 117.9 ± 23.7 (9) 4.4 ± 0.8 (9) 15.7 ± 5.5 (9)
500 M 12.0 ± 0.8 (8) 21.4 ± 3.3 (8) 110.2 ± 28.3
(10)
3.9 ± 1.0 (10) 15.8 ± 5.4 (10)
1000 M 11.4 ± 0.6 (10) 21.2 ± 4.5 (10) 105.8 ± 21.9*
(10)
3.7 ± 0.7 (10) 13.8 ± 4.2 (10)
0 F 11.0 ± 1.0 (10) 19.7 ± 3.4 (10) 108 ± 22.4 (10) 3.7 ± 0.9 (10) 10.9 ± 2.4 (10)
250 F 10.5 ± 0.3 (9) 18.9 ± 2.4 (9) 108.5 ± 19.1 (10) 4.2 ± 2.6
(10)
11.5 ± 2.3 (10)
500 F 10.6 ± 0.6 (10) 19.0 ± 2.4 (10) 133.9 ± 25.1* (10) 4.2 ± 0.6 (10) 12.8 ± 2.9 (10)
1000 F 10.6 ± 1.0 (10) 18.6 ± 2.3 (10) 139.9 ± 24.2* (10) 4.2 ± 0.8 (10) 11.3 ± 2.5 (10)

SD = standard deviation; PT = prothrombin time; APTT = activated partial thromboplastin time; T3 = triiodothyronine; T4 = thyroxine; TSH = thyroid stimulating hormone.

a

Number of samples.

*

Statistically significant when compared to the concurrent control, < 0.05.