Table 7.
Coagulation tests and hormone analyses.
| Dose level (mg/kg/day) | Sex | PT (seconds) ± SD | APTT (seconds) ± SD | Total T3 (ng/dL) ± SD | Total T4 (μg/dL) ± SD | Total TSH (ng/mL) ± SD |
|---|---|---|---|---|---|---|
| 0 | M | 11.9 ± 0.7 (10)a | 21.9 ± 3.9 (10) | 136.7 ± 38.9 (10) | 4.5 ± 1.3 (10) | 14.7 ± 8.7 (10.0) |
| 250 | M | 12.0 ± 1.2 (9) | 20.6 ± 2.9 (9) | 117.9 ± 23.7 (9) | 4.4 ± 0.8 (9) | 15.7 ± 5.5 (9) |
| 500 | M | 12.0 ± 0.8 (8) | 21.4 ± 3.3 (8) | 110.2 ± 28.3 (10) |
3.9 ± 1.0 (10) | 15.8 ± 5.4 (10) |
| 1000 | M | 11.4 ± 0.6 (10) | 21.2 ± 4.5 (10) | 105.8 ± 21.9* (10) |
3.7 ± 0.7 (10) | 13.8 ± 4.2 (10) |
| 0 | F | 11.0 ± 1.0 (10) | 19.7 ± 3.4 (10) | 108 ± 22.4 (10) | 3.7 ± 0.9 (10) | 10.9 ± 2.4 (10) |
| 250 | F | 10.5 ± 0.3 (9) | 18.9 ± 2.4 (9) | 108.5 ± 19.1 (10) | 4.2 ± 2.6 (10) |
11.5 ± 2.3 (10) |
| 500 | F | 10.6 ± 0.6 (10) | 19.0 ± 2.4 (10) | 133.9 ± 25.1* (10) | 4.2 ± 0.6 (10) | 12.8 ± 2.9 (10) |
| 1000 | F | 10.6 ± 1.0 (10) | 18.6 ± 2.3 (10) | 139.9 ± 24.2* (10) | 4.2 ± 0.8 (10) | 11.3 ± 2.5 (10) |
SD = standard deviation; PT = prothrombin time; APTT = activated partial thromboplastin time; T3 = triiodothyronine; T4 = thyroxine; TSH = thyroid stimulating hormone.
a
Number of samples.
*
Statistically significant when compared to the concurrent control, p < 0.05.