Table 2.
Parameter | Unit | Mean estimated values |
||
---|---|---|---|---|
i.v | i.p | p.o | ||
AUC0–t | h mg/l | 5.96 | 1.87 | 0.40 |
AUC0–inf | h mg/l | 6.22 | 1.90 | 0.47 |
AUMC0–t | h mg/l | 8.96 | 3.14 | 1.13 |
AUMC0–inf | h mg/l | 9.23 | 3.30 | 1.33 |
MRT | hour | 1.48 | 1.74 | 2.86 |
t1/2 | minutes | 11.40 | 53.40 | 68.40 |
Tmax | minutes | 10.00 | 45.00 | 45.00 |
Cmax | μg/ml | 8.63 | 2.10 | 0.14 |
peak.concn | uM | 18.84 | 4.56 | 0.30 |
Tlast | minutes | 480.00 | 360.00 | 360.00 |
Clast | μg/ml | 0.06 | 0.00 | 0.06 |
Bioavailability | % | 100.00 | 31.37 | 6.71 |