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TEM images of WI-38 fibroblasts treated with Ni NWs. Internalized 1 μm long Ni NWs (right column) after (A) 24, (B) 48 and (C) 72 h. The Ni NWs were found inside vesicles, most likely lysosomes (red arrows). In some of the pictures alteration of the normal size of the endoplasmic reticulum was observed (black narrows). Their respective controls are shown in the left column. Scale bars = 1 μm.
