Fig. 2.

The histological photomicrographs of the liver in bile duct ligated rats and the effect of taurine administration (See also Table 2). Representative photomicrographs of liver sections processed for H&E (upper row) and Masson’s trichrome (lower row) staining (200×). Scale bar, 1060 μm. Sham (A&E), BDL (B&F), BDL+ Taurine 500 mg/kg (C&G), and BDL + Taurine 1000 mg/kg (D&H). Extensive tissue necrosis and bridging fibrosis in untreated BDL rats are shown in B and F (Yellow arrow; Ishak grade 5; Table 2). All these lesions were markedly attenuated in Taurine-treated BDL animals (C&D), G (Ishak grade 3; Table 2) and H (Ishak grade 2; Table 2). No significant pathological changes were observed in liver tissues with the sham operation (A) (Table 2). Red arrow: Confluent necrosis. Green arrow: focal necrosis. Blue arrow: Portal inflammation. Orange: Sinusoidal Congestion. BDL: Bile duct ligated.