Fig. 3.

The effect of taurine administration on liver histopathological changes in thioacetamide-treated rats (See also Table 2 for grading of tissue histopathological changes). Representative photomicrographs of liver sections processed for H&E staining (400×). Scale bar, 530 μm. A: Control. B: Thioacetamide‐treated rats. C: Thioacetamide + Taurine 500 mg/kg D: Thioacetamide + Taurine 1000 mg/kg. Signs of hepatocytes apoptosis (red arrow), fatty changes and ballooning degeneration (black arrow), inflammation (yellow arrow), developed in thioacetamide-administered animals (B) (Table 2). Taurine administration significantly alleviated thioacetamide-induced lesions (C & D) and no tissue necrosis was observed in taurine-treated (1000 mg/kg, i.p) animals (D) (Table 2).