Fig. 4.

Liver histopathology of acetaminophen-treated mice. Acetaminophen (1000 mg/kg, i.p.) was administered to mice and animals were sacrificed 24 h after drug treatment. Liver sections were subjected to hematoxylin-eosin (H&E) staining (200 × ). Scale bar, 1060 μm. A: represents normal mice liver histopathology. B: Acetaminophen-challenged group. C: Acetaminophen + Taurine 500 mg/kg and D: Acetaminophen + Taurine 1000 mg/kg. Congestion (Orange arrow), tissue focal (green arrow) and confluent necrosis (red arrow) were detected in acetaminophen-treated animals (B) (Table 2). No sign of liver necrosis was detected when taurine was administered to acetaminophen-intoxicated mice (C&D) (Table 2).