Table 1.
Treatment | Plasma ALT (U/l) |
Plasma AST (U/l) |
Plasma LDH (U/l) |
Plasma ALP (U/l) |
Plasma Bilirubin (mg/dl) | Plasma ammonia (μg/dl) |
Liver GSH (μmol/mg tissue) |
Liver TBARS (nmol/mg tissue) |
Brain edema (% brain water) |
Survival Rate (%) |
---|---|---|---|---|---|---|---|---|---|---|
Control (vehicle-treated rat) | 45 ± 3 | 84 ± 9 | 316 ± 68 | 571 ± 86 | 0.09 ± 0.01 | 223 ± 22 | 67.86 ± 9.35 | 1.87 ± 0.22 | 81 ± 3 | 100 |
Control (vehicle-treated mice) | 17 ± 5 | 48 ± 7 | 164 ± 42 | 456 ± 106 | 0.03 ± 0.01 | 241 ± 36 | 75.80 ± 10.50 | 1.86 ± 0.23 | 79 ± 4 | 100 |
Taurine-treated rats (1000 mg/kg) | 33 ± 7 | 72 ± 9 | 284 ± 57 | 396 ± 123 | 0.08 ± 0.03 | 186 ± 53 | 82.53 ± 7.45 | 1.04 ± 0.51 | 78 ± 5 | 100 |
Taurine-treated mice (1000 mg/kg) | 22 ± 6 | 53 ± 8 | 209 ± 18 | 286 ± 98 | 0.07 ± 0.03 | 304 ± 56 | 84.31 ± 4.29 | 1.23 ± 0.61 | 82 ± 4 | 100 |
TAA −treated rats | 751 ± 108 * | 1583 ± 366* | 3151 ± 269* | 755 ± 99 | 0.36 ± 0.04* | 625 ± 39* | 14.25 ± 2.30* | 9.57 ± 1.57* | 87 ± 1 | 100 |
Bile duct ligated (BDL) ratsd | 335 ± 38* | 237 ± 55* | 606 ± 72* | 1738 ± 370* | 12.53 ± 0.45* | 938 ± 70* | 26.47 ± 3.95* | 3.93 ± 1.10* | 92 ± 2* | 66.66* |
APAP-treated miced | 536 ± 130* | 627 ± 102* | 1083 ± 279* | 569 ± 65 | 0.22 ± 0.02* | 1110 ± 42* | 29.90 ± 3.70* | 10.85 ± 0.7* | 93 ± 3* | 66.66* |
TAA + Taurine 500 mg/kg | 131 ± 29a | 476 ± 117 a | 890 ± 58a | 680 ± 75 | 0.20 ± 0.03a | 490 ± 41a | 17.75 ± 2.32 | 2.44 ± 0.13a | 82 ± 2 | 100 |
TAA + Taurine 1000 mg/kg | 118 ± 34a | 324 ± 67a | 618 ± 143a | 596 ± 121 | 0.14 ± 0.02a | 220 ± 22a | 21.23 ± 1.45a | 2.60 ± 0.40a | 83 ± 2 | 100 |
BDL + Taurine 500 mg/kg | 139 ± 31b | 114 ± 10b | 321 ± 40b | 583 ± 92b | 2.80 ± 0.05b | 278 ± 26b | 50.00 ± 5.51b | 2.60 ± 0.12b | 80 ± 3b | 100b |
BDL + Taurine 1000 mg/kg | 134 ± 19b | 128 ± 40b | 295 ± 42b | 681 ± 80 b | 2.62 ± 0.08b | 228 ± 38b | 52.1 ± 4.28b | 2.2 ± 0.23 b | 78 ± 3b | 100b |
APAP + Taurine 500 mg/kg | 98 ± 10c | 330 ± 30c | 226 ± 58c | 609 ± 111 | 0.06 ± 0.01c | 791 ± 63c | 50.00 ± 1.50c | 7.40 ± 0.28c | 81 ± 3c | 100 c |
APAP + Taurine 1000 mg/kg | 79 ± 13c | 322 ± 80c | 280 ± 47c | 551 ± 54 | 0.026 ± 0.01c | 708 ± 52c | 53.13 ± 4.30 c | 6.61 ± 0.30 c | 83 ± 2 c | 100 c |
Data are given as Mean ± SEM for each group (n = 6). TAA: Thioacetamide, BDL: Bile duct ligated, APAP: Acetyl Para amino phenol, Acetaminophen.
*Indicates significantly different as compared to control animals (P < 0.05).
Shows significant difference as compared to thioacetamide-treated rats (P < 0.05).
Indicates significant difference as compared to BDL rats (P < 0.05).
Indicates significant difference as compared to APAP-treated mice (P < 0.05).
Two out of six animals were death (n = 4).