Table 2.
Liver histopathological changes in different experimental groups.
| Pathologic assessment Treatment |
Confluent Necrosis |
Focal Necrosis | Portal Inflammation |
Interface Hepatitis |
Ballooning degeneration | Fatty changes | Total grade | Ishak stage of liver fibrosis |
|---|---|---|---|---|---|---|---|---|
| Control (vehicle-treated rats) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – |
| Control (vehicle-treated mice) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – |
| TAA −treated rats | 0 | 2 | 3 | 0 | 3 | 1 | 8 | – |
| Bile duct ligated (BDL) rats | 5 | 2 | 2 | 2 | 1 | 0 | 12 | 5 |
| APAP-treated mice | 3 | 3 | 0 | 0 | 0 | 1 | 7 | – |
| TAA + Taurine 500 mg/kg | 0 | 1 | 2 | 0 | 2 | 0 | 5 | – |
| TAA + Taurine 1000 mg/kg | 0 | 2 | 1 | 0 | 1 | 0 | 4 | – |
| BDL + Taurine 500 mg/kg | 0 | 0 | 2 | 2 | 1 | 0 | 5 | 3 |
| BDL + Taurine 1000 mg/kg | 0 | 0 | 1 | 1 | 1 | 0 | 3 | 2 |
| APAP+ Taurine 500 mg/kg | 0 | 0 | 1 | 1 | 1 | 1 | 4 | – |
| APAP+ Taurine 1000 mg/kg | 0 | 0 | 1 | 1 | 0 | 1 | 3 | – |