Table 2.

Effects of Antituberculous Drugs on Female Reproductive Hormones in Rats.

	Oestroge (U/l)	Prolactin (U/l)	Progesterone (U/l)
Control	0.36 ± 0.12	0.06 ± 0.03	0.12 ± 0.05
RIPE	1.05 ± 0.21*(−191.7) [−75]	0.08 ± 0.03 (−33.3) [0]	0.54 ± 0.25*(−350.0)[−400]

NB: Result expressed as Mean ± SEM; n = 8; Control (DW: Distilled Water, 1.6 ml); Values in parenthesis represent% change; (−) increase; (+) decrease. ⁽⁾ % mean, when compared with control distilled water; ^[] SEM when compared with control. ^*p < 0.05 change relative to control group. RIPE: (Rifampicin + Isoniazid + Pyrazinamide + Ethambutol, (92.5 mg/m² body surface area, body weight 60 kg man; Body Surface Area (BSA): man = 1.6; BSA rat (0.16 kg) = 0.025; k_m = Weight/BSA; k_m rat: 6; K_m man: 37).