Fig. 1.

Effect of bupropion (BUP) on ambulatory activity in ICR mice. The panels show normalized ambulatory activity that was obtained by normalizing actual ambulatory activity to the total ambulatory activity during the 30-min adaptation period before administration in each mouse. (a) Alterations in normalized ambulatory activity before and after subcutaneous administration of saline or 5 or 10 mg/kg BUP. Symbols show median values of normalized ambulatory activity for each 10-min period plotted against the midpoint of the measurement period, and vertical lines denote the first and third quartiles. The arrow indicates the time point for the administration of saline or 5 or 10 mg/kg BUP. (b) Total normalized ambulatory activity for 60 min after administration of saline or 5 or 10 mg/kg BUP. Data are shown using a box plot. *P < 0.05 compared with the saline control. The numbers of animals used were 40–120 (N = 40–120).