Fig. 7.

Alterations in dopamine (DA), its metabolites DOPAC and HVA, and 5-HIAA, a metabolite of serotonin (5-HT), in microdialysis samples obtained from the CPu of mice before and after administration of saline or 10 mg/kg BUP. The actual measured values for each compound just before administering saline or BUP in each mouse were defined as the baseline values, and all measured values were expressed as ratios to the baseline values. Symbols denote mean values that were plotted against the midpoint of the measurement period, and vertical lines indicate standard error of the mean (SEM). *P < 0.05 compared with saline. N = 17–20.