Table 2.
Summary data of peak values of the 22 phospholipids by subgroup, presented as median and range.
| Phospho-lipids | Therapeutic (Gr A) (μM) | Control (Gr B) (μM) | Overdose (Gr C) (μM) | PLS-DA VIP | Kruskal-Wallis p_value | Dunn’s test for Multiple comparisons (Benjamini-Hochberg adjusted p_value) |
||
|---|---|---|---|---|---|---|---|---|
| B-A | C-A | C-B | ||||||
| lysoPC a C14:0 | 1.97 (1.54–3.82) |
2.02 (0.99–2.63) |
3.41 (2.50–4.75) |
1.72 | <0.0004 | NS* | <0.002 | <0.002 |
| lysoPC a C16:1 | 3.13 (1.65–4.41) |
2.86 (0.01–4.99) |
4.16 (2.78–7.19) |
1.34 | <0.03 | NS | NS | <0.03 |
| lysoPC a C24:0 | 0.43 (0.29–1.02) |
0.38 (0.11–2.54) |
0.28 (0.16–0.47) |
1.20 | <0.009 | NS | <0.02 | <0.02 |
| lysoPC a C26:1 | 2.99 (2.68–3.45) |
2.80 (1.20–3.22) |
0.36 (0.15–0.76) |
2.53 | <0.0000008 | NS | <0.00002 | <0.00004 |
| lysoPC a C28:1 | 0.99 0.83–1.59) |
0.70 (0.11–1.65) |
0.57 (0.35–0.92) |
1.57 | <0.002 | <0.047 | <0.002 | <0.047 |
| PC aa C30.0 | 2.79 (1.9–6.47) |
2.26 (0.33–4.11) |
3.35 (2.43–10.45) |
1.42 | <0.003 | NS | NS | <0.002 |
| PC aa C32.0 | 17.85 (12.57–49.03) |
13.87 (0.11–42.20) |
20.56 (12.79–46.67) |
1.40 | <0.003 | <0.048 | NS | <0.002 |
| PC aa C32.1 | 20.07 (9.47–29.52) |
10.42 (0.14–25.10) |
18.65 (11.54–57.89) |
1.42 | <0.0007 | <0.011 | NS | <0.002 |
| PC aa C40.1 | 0.44 (0.26–0.84) |
0.45 (0.30–1.42) |
0.34 (0.28–0.94) |
1.25 | <0.03 | NS | NS | <0.022 |
| PC aa C40.2 | 0.30 (0.26–0.82) |
0.36 (0.05–1.88) |
0.26 (0.12–0.35) |
1.24 | <0.007 | NS | NS | <0.007 |
| PC aa C40.3 | 0.44 (0.36–1.25) |
0.47 (0.01–1.41) |
0.40 (0.28–0.58) |
1.16 | <0.043 | NS | NS | <0.04 |
| PC aa C42.6 | 0.76 (0.65–1.27) |
0.78 (0.52–1.96) |
0.56 (0.39–0.89) |
1.40 | <0.003 | NS | <0.009 | <0.007 |
| PC ae C34.2 | 7.77 (5.94–16.11) |
11.55 (0.03–16.47) |
8.62 (6.47–11.49) |
1.72 | <0.0004 | <0.002 | NS | <0.003 |
| PC ae C34.3 | 5.20 (3.27–18.52) |
10.38 (0.07–15.46) |
6.01 (3.43–11.60) |
1.73 | <0.0001 | <0.0007 | NS | <0.0008 |
| PC ae C36.2 | 12.70 (10.94–27.60) |
14.51 (0.04–23.20) |
10.49 (8.87–16.24) |
1.49 | <0.002 | NS | NS | <0.0009 |
| PC ae C36.3 | 5.78 (4.37–11.70) |
9.15 (5.81–13.62) |
6.13 (4.64–8.32) |
1.80 | <0.0001 | <0.001 | NS | <0.0005 |
| PC ae C36.5 | 6.47 (4.2–35.65) |
13.36 (0.04–38.27) |
10.38 (6.80–18.20) |
1.59 | <0.0009 | <0.0007 | NS | <0.045 |
| PC ae C38.2 | 1.95 (1.09–5.48) |
1.98 (0.05–3.60) |
1.25 (0.80–4.20) |
1.76 | <0.0004 | NS | NS | <0.0006 |
| PC ae C38.6 | 4.34 (2.70–15.58) |
7.54 (0.03–11.54) |
5.51 (3.76–8.60) |
1.61 | <0.002 | <0.002 | NS | <0.019 |
| PC ae C42.0 | 0.63 (0.46–1.11) |
0.58 (0.45–1.61) |
0.47 0.38–0.87) |
0.95 | <0.022 | NS | <0.03 | <0.03 |
| PC ae C42.2 | 0.33 (0.11–0.95) |
0.38 (0.20–0.76) |
0.29 (0.13–0.54) |
1.23 | <0.036 | NS | NS | <0.045 |
| PC ae C44.3 | 0.16 (0.05–0.33) |
0.12 (0.01–0.25) |
0.09 (0.03–0.21) |
1.44 | <0.01 | NS | <0.03 | <0.03 |
*
NS represents non-significant p values.