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Aquaporin 1 (AQP1) was selected for further analysis as a candidate gene. A, Heat map of consistent K means clustered z-scores of the differential expression genes regulating bile secretion between cholangiocarcinoma and matched noncancerous tissues based on R2 applications. B, Significant expression variation of AQP1 among cholangiocarcinoma samples. C, The AQP1 expression variation in 17 fresh tissues, which confirmed the finding.
