Fig. 1.

Toxicity of BAP, CRY and DALP in HaCaT wild-type (WT) or AHR knockdown (AHR-KD) cells. Viability was determined via MTT assay. Cells were treated with 7 different concentrations (0.1–20 μM) of BAP (A) and CRY (B) for 48 h. For DALP (C) 8 additional concentrations (0.01–0.08 μM) were tested due to the strong cytotoxicity of this compound emerging in WT cells. Controls contained 0.1% DMSO (vehicle). Each experiment was repeated three times and data were expressed as mean ± SD. The x-axis depicts the concentrations of the respective PAH applied, the y-axis shows the viability of the treated cells in percent compared to the controls (set to 100%).