Fig. 5.

Differential alterations of metabolomics profiles caused by BAP, CRY and DALP in HaCaT WT cells. Venn diagrams of up- and down-regulated levels of metabolites (A). Volcano plots of metabolites influenced by each single PAH compared to control; BAP (B), CRY (C) and DALP (D). Fold changes were calculated as the ratio between the median of the two groups compared. The significance expressed as p-values is calculated by a two-sided, unpaired t-test. (B–D) The x-axes represent the fold changes as log2 values of the ratio between the median of the treated cells compared to untreated controls. The y-axes represent the −log10 values of the determined p-values via t-test. Axes on the right side represent the p-values (p < 0.05 is regarded as significant). On the top axis, fold changes are presented. Abbreviations used: AAs, amino acids; ACs, acylcarnitines; BAs, biogenic amines; PCs, phosphatidylcholines; LPCs, lysophosphatidylcholines; SMs, sphingomyelins.