Table 3.
Food and acrylamide consumption of male F344 rats in a 30-week feeding study of acrylamide.
| Dose | Mean food consumptiona (g/kg BW/day) (Relative percent in comparison to Control) |
||||||
|---|---|---|---|---|---|---|---|
| Week 1 | Week 5 | Week 10 | Week 15 | Week 20 | Week 25 | Week 30 | |
| Control | 81.1 ± 2.5 | 55.8 ± 1.3 | 46.7 ± 1.3 | 41.2 ± 1.1 | 39.5 ± 0.7 | 37.9 ± 0.6 | 34.5 ± 0.6 |
| 0.5 mg/kg | 78.9 ± 1.0 (97) |
53.9 ± 0.7 (97) |
44.6 ± 0.9 (95) |
39.4 ± 0.6 (96) |
39.4 ± 0.7 (100) | 35.9 ± 0.5 (95) |
33.9 ± 0.4 (98) |
| 1.0 mg/kg | 78.7 ± 1.3 (97) |
53.5 ± 0.7 (96) |
44.6 ± 0.6 (95) |
39.7 ± 0.6 (96) |
40.0 ± 1.2 (101) | 36.3 ± 0.6 (96) |
33.6 ± 0.5 (97) |
| 2.0 mg/kg | 79.7 ± 1.3 (98) |
54.9 ± 0.9 (98) |
43.9 ± 0.9 (94) |
40.0 ± 0.5 (97) |
39.8 ± 0.5 (101) | 36.9 ± 0.4 (97) |
33.9 ± 0.4 (98) |
| Dose | Mean acrylamide consumption (μg/kg BW/day) |
||||||
|---|---|---|---|---|---|---|---|
| Week 1 | Week 5 | Week 10 | Week 15 | Week 20 | Week 25 | Week 30 | |
| Control | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 0.5 mg/kg | 39.5 ± 0.5 | 26.9 ± 0.4 | 22.3 ± 0.5 | 19.7 ± 0.3 | 19.7 ± 0.4 | 17.9 ± 0.2 | 17.0 ± 0.2 |
| 1.0 mg/kg | 78.7 ± 1.3 | 53.5 ± 0.7 | 44.6 ± 0.6 | 39.7 ± 0.6 | 40.0 ± 1.2 | 36.3 ± 0.6 | 33.6 ± 0.5 |
| 2.0 mg/kg | 159.4 ± 2.5 | 109.7 ± 1.8 | 87.9 ± 1.9 | 79.9 ± 1.1 | 79.6 ± 1.1 | 73.9 ± 0.8 | 67.8 ± 0.8 |
a
Food consumption expressed as mean food consumed per kg body weight of rat per day ± standard error of the mean. Food was measured by cage, divided by number of days since previous measurement, divided by 2 rats per cage, divided by mean body weight of the 2 rats.