Table 4.
Serum clinical biochemistry of male rats in a 30-week feeding study of acrylamide.
| Control | 0.5 mg/kg | 1.0 mg/kg | 2.0 mg/kg | |
|---|---|---|---|---|
| Albumin (g/L) | 32.0 ± 1.0 | 32.8 ± 0.7 | 32.4 ± 0.7 | 32.4 ± 0.7 |
| ALT (U/L) | 59.5 ± 6.6 | 55.1 ± 3.9 | 76.3 ± 25.9 | 58.5 ± 4.6 |
| ALP (U/L) | 125.3 ± 8.3 | 120.6 ± 3.4 | 149.2 ± 18.7 | 126.9 ± 5.7 |
| Amylase (U/L) | 3112 ± 63 | 3163 ± 89 | 3034 ± 109 | 2931 ± 59 |
| AST (U/L) | 81.3 ± 4.7 | 79.3 ± 5.0 | 80.8 ± 9.2 | 77.4 ± 4.2 |
| BUN (mmol/L) | 6.3 ± 0.3 | 6.3 ± 0.1 | 5.9 ± 0.2 | 6.1 ± 0.2 |
| Calcium (mmol/L) | 2.95 ± 0.11 | 3.00 ± 0.08 | 2.99 ± 0.08 | 2.99 ± 0.09 |
| Chloride (mmol/L) | 98.6 ± 0.8 | 98.4 ± 0.9 | 98.5 ± 0.9 | 98.6 ± 0.9 |
| Cholesterol (mmol/L) | 3.1 ± 0.1 | 3.3 ± 0.1 | 3.1 ± 0.1 | 3.3 ± 0.1 |
| HDL (mmol/L) | 0.86 ± 0.05 | 0.88 ± 0.03 | 0.83 ± 0.03 | 0.87 ± 0.04 |
| LDL (mmol/L) | 0.29 ± 0.01 | 0.31 ± 0.02 | 0.30 ± 0.01 | 0.30 ± 0.02 |
| CK (U/L) | 448.7 ± 28.0 | 388.2 ± 30.1 | 340.1 ± 31.6 | 309.2 ± 38.0* |
| CO2 (mmol/L) | 29.5 ± 0.3 | 29.7 ± 0.2 | 30.4 ± 0.2 | 31.0 ± 0.3* |
| Creatinine (mmol/L) | 30 ± 3 | 30 ± 3 | 32 ± 3 | 29 ± 2 |
| Glucose (mmol/L) | 8.2 ± 0.5 | 8.2 ± 0.4 | 9.2 ± 0.6 | 9.6 ± 0.6 |
| Iron (μmol/L) | 33.55 ± 0.72 | 33.01 ± 0.33 | 31.40 ± 0.71 | 31.12 ± 0.92 |
| Lipase (U/L) | 6.8 ± 0.6 | 6.7 ± 0.8 | 6.7 ± 0.9 | 8.2 ± 0.8 |
| Magnesium (mmol/L) | 0.59 ± 0.03 | 0.61 ± 0.02 | 0.61 ± 0.01 | 0.62 ± 0.02 |
| Phosphorus (mmol/L) | 1.8 ± 0.1 | 2.0 ± 0.1 | 1.9 ± 0.1 | 2.0 ± 0.1 |
| Potassium (mmol/L) | 4.1 ± 0.1 | 4.3 ± 0.1 | 4.2 ± 0.1 | 4.1 ± 0.1 |
| Sodium (mmol/L) | 140.8 ± 1.0 | 140.9 ± 0.8 | 140.7 ± 0.7 | 140.8 ± 0.8 |
| Total Protein (g/L) | 68.6 ± 1.7 | 70.2 ± 0.6 | 68.8 ± 0.2 | 69.5 ± 0.9 |
| Triglycerides (mmol/L) | 3.17 ± 0.17 | 3.65 ± 0.28 | 3.61 ± 0.25 | 4.05 ± 0.27 |
| Testosterone (ng/mL) | 1.791 ± 0.325 | 2.019 ± 0.205 | 2.390 ± 0.227 | 2.534 ± 0.417 |
An asterisk (*) denotes value that is significantly different (p < 0.05) from the control (no acrylamide exposure). ALT—alanine transaminase, ALP—alkaline phosphatase, AST—aspartate transaminase, BUN—blood urea nitrogen, HDL—high density lipoprotein, LDL—low density lipoprotein, CK—creatine kinase, CO2—carbon dioxide.