Table 5.
Hematology of male F344 rats in a 30-week feeding study of acrylamide.
| Control | 0.5 mg/kg | 1.0 mg/kg | 2.0 mg/kg | |
|---|---|---|---|---|
| WBC | 4.2 ± 0.3 | 4.6 ± 0.2 | 4.3 ± 0.1 | 4.1 ± 0.1 |
| RBC | 8.57 ± 0.06 | 8.78 ± 0.08 | 8.70 ± 0.05 | 8.67 ± 0.06 |
| HGB | 142 ± 1 | 146 ± 1* | 144 ± 1 | 145 ± 1* |
| HCT | 0.414 ± 0.003 | 0.424 ± 0.003 | 0.421 ± 0.002 | 0.422 ± 0.002 |
| MCV | 48 ± 0 | 48 ± 0 | 48 ± 0 | 49 ± 0 |
| MCH | 16.6 ± 0.1 | 16.6 ± 0.1 | 16.6 ± 0.1 | 16.7 ± 0.1 |
| MCHC | 343 ± 1 | 344 ± 1 | 343 ± 1 | 345 ± 1 |
| RDW | 12.9 ± 0.1 | 12.7 ± 0.1 | 12.6 ± 0.1 | 12.7 ± 0.2 |
| PLT | 537 ± 8 | 540 ± 8 | 532 ± 8 | 517 ± 12 |
| MPV | 7.2 ± 0.1 | 7.1 ± 0.1 | 7.1 ± 0.1 | 7.2 ± 0.2 |
| NE% | 34.1 ± 1.4 | 35.8 ± 1.5 | 33.2 ± 1.1 | 31.1 ± 1.8 |
| LY% | 59.6 ± 1.4 | 58.2 ± 1.7 | 60.5 ± 0.9 | 62.2 ± 1.7 |
| MO% | 3.5 ± 0.3 | 3.1 ± 0.2 | 3.3 ± 0.4 | 3.5 ± 0.4 |
| EO% | 2.5 ± 0.1 | 2.5 ± 0.2 | 2.8 ± 0.2 | 2.9 ± 0.2 |
| BA% | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.4 ± 0.0 |
| NE# | 1.43 ± 0.13 | 1.66 ± 0.14 | 1.44 ± 0.06 | 1.27 ± 0.09 |
| LY# | 2.50 ± 0.17 | 2.65 ± 0.10 | 2.62 ± 0.08 | 2.53 ± 0.07 |
| MO# | 0.15 ± 0.02 | 0.14 ± 0.02 | 0.14 ± 0.02 | 0.14 ± 0.02 |
| EO# | 0.11 ± 0.01 | 0.12 ± 0.01 | 0.12 ± 0.01 | 0.12 ± 0.01 |
| BA# | 0.01 0.00 | 0.02 0.00 | 0.01 0.00 | 0.02 0.00 |
An asterisk (*) denoted those that are significantly different (p < 0.05) from controls.
WBC—white blood cell, RBC − red blood cell, HGB—hemoglobin, HCT—hematocrit, MCV—mean corpuscular volume, MCH—mean corpuscular hemoglobin, MCHC—mean corpuscular hemoglobin concentration, RDW—red blood cell distribution width, PLT—platelet count, MPV—mean platelet volume, NE—Neutrophils, LY—Lymphocytes, MO—Monocytes, EO —Eosinophils, BA—Basophils.