Table 6.
Leukocyte characterization of the thymus and whole blood of male rats in a 30-week feed study of acrylamide.
| Control | 0.5 mg/kg | 1.0 mg/kg | 2.0 mg/kg | |
|---|---|---|---|---|
| Whole Blood | ||||
| T lymphocytesa CD3+ |
48.3 ± 2.4 | 50.2 ± 2.7 | 53.4 ± 2.4 | 52.2 ± 3.8 |
| Helper T cellsa CD3+/CD4+ |
30.6 ± 1.9 | 30.9 ± 1.8 | 32.7 ± 1.8 | 31.4 ± 2.6 |
| Cytotoxic T cellsa CD3+/CD8a+ | 18.3 ± 0.9 | 20.2 ± 1.3 | 21.7 ± 0.8 | 21.8 ± 1.5 |
| B cellsa CD45RA+/CD3- |
13.9 ± 1.8 | 14.1 ± 1.9 | 15.7 ± 2.0 | 16.2 ± 1.5 |
| NKb cellsa CD161a+ (high)/CD3-CD161a+ (med)/CD3- |
2.4 ± 0.2 30.9 ± 2.8 |
2.9 ± 0.3 29.8 ± 4.3 |
3.5 ± 0.5 24.7 ± 4.7 |
2.8 ± 0.2 26.0 ± 5.2 |
| Monocytesa CD4+/CD3- |
7.2 ± 0.9 | 6.1 ± 0.3 | 7.0 ± 0.4 | 7.2 ± 0.5 |
| Thymus | ||||
|
Immature thymocytesa CD4-/CD8- |
4.03 ± 0.29 | 3.92 ± 0.21 | 3.81 ± 0.20 | 4.15 ± 0.22 |
|
Immature thymocytesa CD4+/CD8+ |
84.32 ± 0.57 | 84.32 ± 0.52 | 84.45 ± 0.33 | 84.37 ± 0.49 |
| Helper T cellsa CD4+/CD8- |
8.60 ±0.41 | 8.69 ± 0.30 | 8.61 ± 0.21 | 8.59 ± 0.39 |
| Cytotoxic T cellsa CD4-/CD8+ |
3.07 ± 0.28 | 3.08 ± 0.28 | 3.11 ± 0.26 | 2.88 ± 0.13 |
a
% leukocyte (CD45 + ) cells.
b
Natural Killer.