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Plasma Isoniazid and Acetylisoniazid concentrations in slow and rapid acetylator TB patients (N = 79) after 3 and 6 h from the administration of a dose (5 mg/kg body weight) of INH.
| Slow Acetylators |
Rapid Acetylators |
|||
|---|---|---|---|---|
| 3 h (mg/L) | 6 h (mg/L) | 3 h (mg/L) | 6 h (mg/L) | |
| Isoniazid | 6.79 + 2.70 (2.8–13.10) |
3.5 + 2.25 (0.1–9.5) |
2.37 + 0.6 (1.3–3.5) |
1.53 + 0.67 (0.5–3.1) |
| Acétylisoniazid | 1.52 + 0.60 (0.2–3.7) |
0.77 + 0.6 (0.1–2.2) |
1.13 + 0.8 (0.2–3.1) |
0.41 + 0.32 (0.1–1.2) |
