Figure 16.

Pdot-chlorotoxin bioconjugates for in vivo tumor targeting. A) Fluorescence imaging of healthy brains in wild-type mice (left) and medulloblastoma tumors in ND2:SmoA1 mice (right). Each mouse was injected through the tail vein with 50 μL of a1 μM solution of either the nontargeting PBdot-PEG (top), or targeting PBdot-CTX (middle). As a control, some mice did not receive an injection (bottom). B) Tumor-targeting efficiency by quantifying fluorescence signals in ND2:SmoA1 versus wild-type mice and cerebellum versus frontal lobe. C) Histological examination of the mouse brains in A). The dark purple regions in the H&E-stained cerebellum of ND2:SmoA1 mice confirmed the presence of tumor. Reproduced from Ref. [58] with permission.