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. Author manuscript; available in PMC: 2017 Sep 27.
Published in final edited form as: Cell Rep. 2017 Sep 5;20(10):2396–2407. doi: 10.1016/j.celrep.2017.08.040

Figure 7. Effect of OTU mutations on minigenome and VLP activity.

Figure 7

(A) Minigenome luciferase activity was measured 2 days post transfection. (see Experimental Procedures) (B) CCHF VLPs containing supernatants were harvested at 3 days post-transfection, and transferred to new Huh7 cells. The luciferase signal was determined as a measure for VLP activity. Data are mean ± SD of three biological replicates. *p < 0.05 indicate statistical significance between the wild-type L protein and the individual mutants.