Extended Data Table 1.
The TCR repertoires of 10 epitope-specific populations.
| Name | Species | MHC | Peptide | Virus | No. of subjects | No. of parsed reads | No. of clones1 | Clonality2 | Pshare3-α | Pshare-β | Pshare-αβ |
|---|---|---|---|---|---|---|---|---|---|---|---|
| F2 | mouse | Db | LSLRNPILV | IAV | 9 | 162 | 117 | 0.954 | 3.09E-03 | 2.66E-03 | 0.00E+00 |
| NP | mouse | Db | ASNENMETM | IAV | 24 | 815 | 305 | 0.855 | 7.27E-03 | 3.46E-02 | 2.16E-03 |
| PA | mouse | Db | SSLENFRAYV | IAV | 15 | 620 | 324 | 0.958 | 1.03E-02 | 3.78E-03 | 1.19E-03 |
| PB1 | mouse | Kb | SSYRRPVGI | IAV | 34 | 932 | 642 | 0.968 | 2.46E-02 | 4.82E-03 | 5.91E-04 |
| m139 | mouse | Kb | TVYGFCLL | mCMV | 8 | 124 | 87 | 0.933 | 1.18E-02 | 1.64E-03 | 0.00E+00 |
| M38 | mouse | Kb | SSPPMFRV | mCMV | 14 | 407 | 158 | 0.843 | 6.36E-03 | 1.06E-01 | 2.16E-03 |
| M45 | mouse | Db | HGIRNASFI | mCMV | 1 | 345 | 291 | 0.989 | 8.74E-03 | 6.34E-03 | 1.20E-03 |
| BMLF | human | A0201 | GLCTLVAML | EBV | 6 | 470 | 76 | 0.823 | 5.41E-02 | 2.11E-02 | 4.85E-03 |
| M1 | human | A0201 | GILGFVFTL | IAV | 15 | 453 | 275 | 0.888 | 1.98E-02 | 6.45E-02 | 1.33E-02 |
| pp65 | human | A0201 | NLVPMVATV | hCMV | 10 | 307 | 61 | 0.528 | 1.51E-02 | 2.43E-03 | 0.00E+00 |
1
Two TCRs are considered as belonging to the same clone if they are from the same mouse and have identical nucleotide sequences.
2
Clonality is measured by first computing 1.0-Simpson’s diversity index of the clone size distribution for each subject and then averaging these values over the different subjects with weights based on the size of each subject’s repertoire.
3
Pshare is the estimated rate at which a clone drawn from one subject has an identical amino acid sequence to one drawn from another subject.