Table 4.
Mean Pre-Dialysis Blood Pressure and Serum Concentrations of Cardiac Troponin T and N-terminal-proBNP, by Treatment Group
| Placebo (N = 26) |
600 mg Coenzyme Q10 (N = 18) |
1200 mg Coenzyme Q10 (N = 21) |
|
|---|---|---|---|
|
|
|||
| Troponin T, ng/ml | |||
| Baseline | 0.05 (0.04, 0.07) | 0.11 (0.07, 0.15) | 0.09 (0.04, 0.14) |
| 1 month | 0.08 (0.04, 0.11) | 0.11 (0.07, 0.16) | 0.08 (0.03, 0.13) |
| 2 months | 0.05 (0.04, 0.08) | 0.10 (0.07, 0.14) | 0.08 (0.02, 0.15) |
| 4 months | 0.07 (0.04, 0.10) | 0.11 (0.07, 0.15) | 0.06 (0.02, 0.10) |
| p-valuea | Reference | 0.71 | 0.10 |
| N-terminal-proBNP, pg/ml | |||
| Baseline | 8412 (2672, 13,151) | 8862 (4262, 13,461) | 6794 (2668, 10,920) |
| 1 month | 11,294 (5033, 17,555) | 8857 (2958, 14,757) | 7768 (2443, 13,094) |
| 2 months | 10,740 (5579, 15,901) | 11,169 (4714, 17.624) | 6062 (0, 12,353) |
| 4 months | 9562 (2803, 16,321) | 13,510 (5752, 21,268) | 2601 (0, 5558) |
| p-valuea | Reference | 0.92 | 0.09 |
| Pre-dialysis systolic blood pressure, mmHg | |||
| Baseline | 133 (126, 140) | 144 (134, 155) | 138 (131, 146) |
| 1 month | 136 (127, 145) | 144 (136, 152) | 143 (131, 154) |
| 2 months | 141 (130, 151) | 146 (135, 157) | 143 (131, 154) |
| 4 months | 138 (127, 150) | 140 (131, 150) | 128 (112, 143) |
| p-valuea | Reference | 0.87 | 0.90 |
| Pre-dialysis diastolic blood pressure, mmHg | |||
| Baseline | 73 (67, 79) | 78 (68, 89) | 75 (69, 81) |
| 1 month | 73 (66, 79) | 78 (72, 84) | 77 (68, 85) |
| 2 months | 77 (69, 85) | 79 (70, 87) | 77 (69, 85) |
| 4 months | 75 (68, 82) | 77 (71, 84) | 70 (62 (78) |
| p-valuea | Reference | 0.99 | 0.93 |
Note: Results reported are from the primary intention-to-treat analysis. Values are least squares means (95% confidence interval), adjusted for age, sex, race, and etiology of ESRD.
a
p-value for comparison of average treatment effect from generalized estimating equation model, adjusted for age, sex, race, etiology of ESRD, and baseline measurements; reference group: placebo. Outcome measurements log transformed prior to analysis.