Table 3.

Cox proportional hazards model for disease specific survival

	Localized Disease (n=15,978) HR (95% CI)	p-value	Regional Disease (n=9,909) HR (95% CI)	p-value
Nodes Examined
1–3	1.25 (1.16, 1.35)	p= <.001	1.02 (0.94, 1.10)	p= 0.65
4–6	1.11 (1.03, 1.20)	p= 0.01	1.06 (0.99, 1.15)	p= 0.10
7–9	1.10 (1.00, 1.20)	p= 0.04	1.02 (0.94, 1.11)	p= 0.57
10 +	1.0		1.0
% Nodes Positive
0.01–24% (n=2355)			0.47 (0.43, 0.52)	p= <.001
25–49% (n=1231)			0.67 (0.61, 0.74)	p= <.001
50–100% (n=1426)			1.0
Age at Diagnosis (per year)	1.02 (1.02, 1.03)	p= <.001	1.02 (1.01, 1.02)	p= <.001
Race
White	1.0		1.0
Black	1.21 (1.10, 1.34)	p= <.001	1.03 (0.92, 1.14)	p= 0.64
Other	0.77 (0.68, 0.88)	p= <.001	0.96 (0.85, 1.07	p= 0.45
Sex (Female vs. Male)	0.77 (0.73, 0.82)	p= <.001	0.82 (0.77, 0.87)	p= <.001
Histologic Grade
Grade I	1.0		1.0
Grade II	1.37 (1.24, 1.51)	p= <.001	1.30 (1.16, 1.46)	p= <.001
Grade III	1.72 (1.56, 1.89)	p= <.001	1.62 (1.44, 1.82)	p= <.001
Grade IV	1.82 (1.58, 2.09)	p= <.001	1.57 (1.39, 1.79)	p= <.001
Tumor size (mm)	1.00 (1.00, 1.00)	p= 0.009	1.00 (1.00, 1.01)	p= <.001

CI = Confidence Interval

HR = Hazard ratio