Skip to main content
. 2016 Nov 2;3:832–840. doi: 10.1016/j.toxrep.2016.10.009

Fig. 2.

Fig. 2

Activation of MAPK signalling in Huh7 cells in response to SiO2-NPs. A: Transcripts from the human MAP Kinase Signaling Pathway RT2 Profiler™ PCR Array showing significant up- and down-regulation in Huh7 cells following exposure to 50 μg/ml SiO2-NPs after 24 h. B: Abundance of CJUN, CFOS, FRA1 and CMYC transcripts in Huh7 cells following exposure to 50 μg/ml SiO2-NPs for 24 h C: Abundance of JUND, CJUN, CFOS, FRA1 and CMYC transcripts. D: Abundance of TNF-α transcript. E: Abundance of BIP, XBP-1s, DNAJB9, CHOP and GADD34 transcripts in Huh7 cells following co-exposure to 50 μg/ml SiO2-NPs and 25 μM JNK inhibitor SP600125 for 24 h. Key for C, D and E: white bars: 25 μM SP600; light grey bars: 50 μg/ml SiO2-NPs; dark grey bars: 25 μM SP600 and 50 μg/ml SiO2-NPs. Shown are results of three independent experiments +/−SEM. Significant differences are marked with one asterisk at p = 0.01–0.05, two asterisks at p = 0.001–0.01 and three asterisks at p = 0.0001–0.001.