. 2016 Oct 29;3:841–860. doi: 10.1016/j.toxrep.2016.10.008

Table 2.

Major Metabolites of S9229 in Rat and Human Microsomal Incubations.

Metabolite	m/z (M + H)	Formula	RT (min)	% MS (EIC) Peak Area^a
				Rat (min)			Human (min)
				10	20	60	10	20	60
S9229	264.1958	C₁₆H₂₆NO₂⁺	6.96	36.4	1.93	0.33	86.9	70.6	22.6
M279A-2	280.1907	C₁₆H₂₆NO₃⁺	4.20	0.6	0.6	0.2	0.2	0.3	0.8
M279B-2	280.1907	C₁₆H₂₆NO₃⁺	4.34	0.4	0.4	0.2	0.6	1.2	2.3
M279C-2	280.1907	C₁₆H₂₆NO₃⁺	4.45	0.5	0.5	0.0	0.1	0.3	0.7
M279D-2	280.1907	C₁₆H₂₆NO₃⁺	4.57	28.5	35.7	20.2	3.9	3.6	21.2
M279E-2	280.1907	C₁₆H₂₆NO₃⁺	4.70	1.0	0.7	–	0.8	1.8	5.2
M265A-2	266.1751	C₁₅H₂₄NO₃⁺	3.45	0.8	2.7	8.5	0.0	0.1	0.8
M265B-2	266.1751	C₁₅H₂₄NO₃⁺	3.68	0.2	0.5	0.5	–	–	0.1
M295A-2	296.1856	C₁₆H₂₆NO₄⁺	2.28	0.1	0.2	0.9	–	–	0.2
M295B-2	296.1856	C₁₆H₂₆NO₄⁺	2.36	0.0	0.1	0.3	–	–	–
M295C-2	296.1856	C₁₆H₂₆NO₄⁺	3.42	–	0.1	0.1	0.2	0.4	1.1
M277A-2	278.1751	C₁₅H₂₄NO₄⁺	4.03	–	0.1	0.1	–	–	–
M277B-2	278.1751	C₁₅H₂₄NO₄⁺	5.77	0.2	0.9	2.3	0.1	0.2	0.3
M263A-2	264.1594	C₁₅H₂₂NO₃⁺	4.45	–	0.0	0.7	–	–	–
M249A-2	250.1802	C₁₅H₂₄NO₂⁺	5.55	2.5	1.2	–	0.5	1.0	1.8

% MS peak area relative to S9229 at time = 0.