. 2016 Oct 29;3:841–860. doi: 10.1016/j.toxrep.2016.10.008

Table 5.

Relative Exposure to the Major Metabolites of S807 as a Function of Administered Dose in Male and Female Rats.

Metabolite	Dose (mg/kg bw)	Males				Females
		T_max (hr)	C_max Ratio^a	AUC_last Ratio^b	% Total Metabolite AUC_last^c	T_max (hr)	C_max Ratio^a	AUC_last Ratio^b	% Total Metabolite AUC_last^c
M265(A-B)-1	20	0.31	1.0	1.0	44.17	0.25	1.0	1.0	41.70
	50	0.75	1.94	3.37	45.94	0.38	1.48	2.60	46.58
	200	3.0	4.32	17.7	50.06	0.50	2.66	11.6	48.54
M441B-1	20	4.5	1.0	1.0	29.26	2.2	1.0	1.0	35.74
	50	6.0	2.10	2.17	19.55	2.8	1.83	2.14	32.82
	200	8.0	3.80	3.97	7.42	8.0	4.24	5.49	19.64
M427B-1	20	7.0	1.0	1.0	5.40	5.0	1.0	1.0	10.43
	50	15	1.55	1.86	3.10	4.3	1.33	1.27	5.68
	200	24	3.98	3.20	1.10	8.3	3.05	3.33	3.47
M293A-1	20	0.50	1.0	1.0	7.34	0.44	1.0	1.0	7.25
	50	1.75	2.34	3.26	7.37	1.0	1.28	2.59	8.06
	200	1.5	4.63	8.95	4.20	1.4	3.48	11.8	8.55
M279B-1	20	0.56	1.0	1.0	1.83	0.38	1.0	1.0	2.00
	50	2.5	5.59	13.6	7.65	0.75	2.30	4.94	4.24
	200	6.0	51.1	156	18.19	8.0	17.7	87.1	17.43
M345B-1	20	1.0	1.0	1.0	6.65	0.50	1.0	1.0	0.80
	50	2.0	2.19	4.37	8.96	0.88	1.49	2.43	0.84
	200	5.0	3.96	12.8	5.44	0.88	2.84	6.10	0.49
M281A-1	20	0.38	1.0	1.0	5.25	0.25	1.0	1.0	1.89
	50	0.75	1.73	4.33	7.02	0.38	1.23	1.84	1.49
	200	3.0	6.48	39.2	13.16	0.50	1.73	5.61	1.06
M251A-1	20	0.31	1.0	1.0	0.09	0.25	1.0	1.0	0.19
	50	0.44	2.63	13.8	0.39	0.31	1.63	3.47	0.28
	200	0.50	14.3	73.7	0.44	0.31	12.1	43.7	0.82

C_max Ratio = C_max/C_max at 20 mg/kg bw dose.

AUC Ratio = AUC_last/AUC_last at the 20 mg/kg bw dose.

% Total Metabolite AUC_last =% peak area for a given metabolite as a% of the total peak area of the eight designated metabolites at that dose.