Table 12.
Body, Thymus, and Liver Weight Changes in Rats Treated with S9229 for 28 days Compared to Controls.
| S9229 Dose: | 10 mg/kg bw/day | 30 mg/kg bw/day | 100 mg/kg bw/day |
|---|---|---|---|
| Males | |||
| Body weight (%) | ↑ 3.38% | ↑ 2.74% | ↑ 6.94%* |
| Body weight gain (%, Day 28 vs Day −1) | ↑ 8.50% | ↑ 6.11% | ↑ 16.7%* |
| Food consumption (%) | ↓ 0.55% | ↑ 2.77% | ↑ 5.35% |
| Thymus weight (%) | ↑ 24.1% | ↑ 20.2% | ↑ 26.3%* |
| Thymus/body weight (%) | ↑ 17.9% | ↑ 16.6% | ↑ 17.5% |
| Thymus/brain weight ratio (%) | ↑ 22.9% | ↑ 23.5% | ↑ 26.1%* |
| Liver weight (%) | ↑ 4.89% | ↑ 4.12% | ↑ 16.8%** |
| Liver/body weight (%) | ↑ 0.51% | ↑ 1.08% | ↑ 8.63%** |
| Liver/brain weight ratio (%) | ↑ 3.66% | ↑ 6.93% | ↑ 16.2%** |
| Females | |||
| Body weight (%) | ↓ 4.11% | ↓ 2.53% | ↓ 5.72% |
| Body weight gain (%, Day 28 vs Day −1) | ↓ 12.8% | ↓ 8.28% | ↓ 17.3% |
| Food consumption (%) | ↓ 6.50% | ↓ 1.58% | ↓ 4.36% |
| Thymus weight (%) | ↑ 10.7% | ↓ 4.50% | ↓ 12.0% |
| Thymus/body weight (%) | ↑ 14.3% | ↓ 1.69% | ↓ 6.96% |
| Thymus/brain weight ratio (%) | ↑ 8.71% | ↓ 6.90% | ↓ 12.5% |
| Liver weight (%) | ↓ 5.78% | ↓ 2.86% | ↓ 6.93% |
| Liver/body weight (%) | ↓ 1.57% | ↑ 0.12% | ↓ 1.44% |
| Liver/brain weight ratio (%) | ↓ 7.08% | ↓ 5.13% | ↓ 7.27% |
↑ = Increased; ↓ = Decreased.
*
Significantly different from control (p < 0.05).
**
Significantly different from control (p < 0.01).