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. Author manuscript; available in PMC: 2018 Aug 30.
Published in final edited form as: Neuron. 2017 Aug 17;95(5):1089–1102.e5. doi: 10.1016/j.neuron.2017.07.036

Figure 4. Pairing light-stimulation of the MEC excitatory inputs with SC stimulation also induces ITDP in CA2.

Figure 4

A. Experimental design of the experiment and injection site of the channelrhodopsin expressing virus. B. Responses obtained in whole-cell current-clamp configuration using light (EC) or electrical (SC) stimulations during ITDP induction (B1) or during the time course (B2) before (black) and 30 min after (grey) ITDP induction. C. Time course of PSPs amplitudes during ITDP. D. Normalized SC (filled circles) and EC (open squares) PSPs amplitudes following ITDP induced using electrical-electrical or light-electrical pairing. Symbols show data for single cells; bars show mean ± S.E.M. E. Immunohistochemistry of the acute hippocampal slice against biocytin, ChR2-YFP, PCP4. Arrowhead in E3 indicates the PCP4 positive soma of the recorded cell. Data from B and E is from the same CA2 PN. See also Figure S5.