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. Author manuscript; available in PMC: 2018 Aug 30.
Published in final edited form as: Neuron. 2017 Aug 17;95(5):1089–1102.e5. doi: 10.1016/j.neuron.2017.07.036

Figure 8. DOR blockade in CA2 reduces social memory and social memory occludes ITDP.

Figure 8

A. Schematic of the direct interaction test for social memory. B. Interaction time of saline (B1) and naltrindole-injected (B2) animals in trials 1 and 2 (symbols from individual animals) and superimposed mean ± SEM data (B3). C. Percent reduction of interaction time from trial 1 to trial 2. D. Mini-Ruby infusion in the hippocampus and immunohistochemistry for RGS14. E. Time course of mean ± SEM normalized SC PSP amplitude obtained in whole-cell current-clamp following ITDP induction. Slices were prepared from mice that either experienced a 2-min interaction with a novel juvenile male (social novelty) or were continuously housed with littermates (social familiarity). Note pronounced reduction in ITDP in response to social novelty D. ITDP of PSPs evoked by stimulation of SC (filled circles) or EC (open squares) inputs to CA2 PNs in slices from indicated groups of animals. Symbols show data for single cells; bars show mean ± SEM. See also Figure S8.