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. 2017 Sep 27;12(9):e0184500. doi: 10.1371/journal.pone.0184500

Table 1. Allergy-associated SNPS in LD with dynamic peaks in the TSLP TAD.

Locations of dynamic peaks containing SNPs that are in LD with allergic disease associated SNPs. R2 indicates LD based on 1000 genomes phase 1 CEU data. Abbreviations: AR- allergic rhinitis; AD- atopic dermatitis; EoE- eosinophilic esophagitis; CR- chronic rhinitis; eQTL- expression quantitative trait locus.

Peak Location Peak Class SNP in Peak Allergy SNP R2 Association Association Reference
chr5 110403882 110404338 Barrier-deficient rs17551370 rs17551370 NA AR, total serum IgE [42]
rs10062929 1 Asthma+AD, EoE, total serum IgE [42, 45, 46]
rs11466750 1 Asthma+AD [46]
          rs11466749 0.85 AD, asthma, AR [42, 46]
chr5 110408867 110409332 Barrier-
deficient
rs2289277 rs2289277 NA total serum IgE, eQTL [4345]
rs3806932 0.95 EoE, CR, eQTL [47]
          rs3806933 0.96 FA, asthma, eQTL [47, 48]
chr5 110153049 110153553 3D rs7735355 rs3853750 1 asthma, hay fever [49]
rs7735519 rs10056340 1 allergic sensitization [50]
        rs7717615        
chr5 110104230  110106393 Barrier-
deficient
rs17506794 rs17513503 0.87 allergic rhinitis [51]
chr5 110176713 110177307 3D rs72774897 rs17513503 0.88 allergic rhinitis [51]
r s1350294 rs3853750 0.82 asthma, hay fever [49]
          rs10056340 0.82 allergic sensitization [50]
chr5 110188917 110189371 Epidermal rs7712806 rs17513503 0.88 allergic rhinitis [51]