Table 1. Allergy-associated SNPS in LD with dynamic peaks in the TSLP TAD.
Peak Location | Peak Class | SNP in Peak | Allergy SNP | R2 | Association | Association Reference | ||
---|---|---|---|---|---|---|---|---|
chr5 | 110403882 | 110404338 | Barrier-deficient | rs17551370 | rs17551370 | NA | AR, total serum IgE | [42] |
rs10062929 | 1 | Asthma+AD, EoE, total serum IgE | [42, 45, 46] | |||||
rs11466750 | 1 | Asthma+AD | [46] | |||||
rs11466749 | 0.85 | AD, asthma, AR | [42, 46] | |||||
chr5 | 110408867 | 110409332 | Barrier- deficient |
rs2289277 | rs2289277 | NA | total serum IgE, eQTL | [43–45] |
rs3806932 | 0.95 | EoE, CR, eQTL | [47] | |||||
rs3806933 | 0.96 | FA, asthma, eQTL | [47, 48] | |||||
chr5 | 110153049 | 110153553 | 3D | rs7735355 | rs3853750 | 1 | asthma, hay fever | [49] |
rs7735519 | rs10056340 | 1 | allergic sensitization | [50] | ||||
rs7717615 | ||||||||
chr5 | 110104230 | 110106393 | Barrier- deficient |
rs17506794 | rs17513503 | 0.87 | allergic rhinitis | [51] |
chr5 | 110176713 | 110177307 | 3D | rs72774897 | rs17513503 | 0.88 | allergic rhinitis | [51] |
r s1350294 | rs3853750 | 0.82 | asthma, hay fever | [49] | ||||
rs10056340 | 0.82 | allergic sensitization | [50] | |||||
chr5 | 110188917 | 110189371 | Epidermal | rs7712806 | rs17513503 | 0.88 | allergic rhinitis | [51] |