Table 3. Diagnostic accuracy of non-invasive tests to predict fibrosis F2-4 in individual studies included in the meta-analysis.
| Author, Year | Test | Cut-off | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | AUC (95% CI) |
|---|---|---|---|---|---|---|---|
| Della-Guardia, 2017 | TE | 12.3 kPa |
43 | 91 | 72 | 76 | 0.78 (0.71–0.85) |
| Crespo, 2016 | TE | 6.8 kPa | 73 | 71 | 57 | 83 | 0.76 (0.64–0.88) |
| Mikołajczyk-Korniak, 2016[38] | TE | 4.7 kPa | 93 | 57 | 90 | 66 | 0.746 (0.53–0.95) |
| Lutz, 2016 | TE | 8.35 kPa | 84.6 | 91.4 | 0.89+/-0.057 | ||
| Barrault, 2013 | TE | 7 kPa | 88.2 | 67.9 | 62.5 | 90.5 | 0.83 (0.71–0.95) |
| Goldsmith, 2013 | TE | 9.3 kPa | 90 | 81 | 75 | 93 | 0.93 (NA) |
| Crespo, 2012 | TE | 8.4 kPa | 82 | 80 | 76 | 86 | 0.87 (NA) |
| Sebagh, 2012 | TE | 7.9 kPa | 62.5 | 66.7 | 45 | 80 | NA |
| Beckebaum, 2010 | TE | 7.3 kPa | 73 | 100 | 100 | 52 | 0.86 |
| Corradi, 2009 | TE | 10.1 kPa | 94 | 89 | 81 | 94 | 0.94 (0.85–0.99) |
| Harada, 2008 | TE | 9.9 kPa | 90 | 91 | 86 | 94 | 0.92 (NA) |
| Rigamonti, 2008 | TE | 7.9 kPa | 81 | 76 | 65 | 88 | 0.85 (0.76–0.92) |
| Carrion, 2006 | TE | 8.5 kPa | 90 | 81 | 79 | 92 | 0.90 (NA) |
| D’Souza, 2016 | APRI | 0.45 | 67 | 79 | 67 | 79 | 0.74 (0.57–0.91) |
| Crespo, 2016 | APRI | 1.36 | 69 | 87 | 75 | 83 | 0.83 (0.73–0.94) |
| Pinto, 2014 | APRI | 0.4 | 83 | 58 | 31 | 94 | 0.74 (0.54–0.95) |
| Kamphues, 2010 | APRI | 0.4845 | 70 | 63 | 80 | 80 | 0.68 (NA) |
| Carrion, 2010 | APRI | - | - | - | - | - | 0.50 |
| Pissaia, 2009 | APRI | 0.5 | 81 | 80 | 62 | 91 | 0.87 (NA) |
| Corradi, 2010 | APRI | 1.3 | 67 | 74 | 55 | 82 | 0.82 (0.64–0.99) |
| Harada, 2008 | APRI | 0.84 | 73 | 91 | 63 | 76 | 0.70 (NA) |
| Toniutto, 2007 | APRI | 1.4 | 76 | 77 | 46 | 93 | 0.80 (NA) |
| Crespo, 2016 | FIB-4 | 3.23 | 77 | 80 | 69 | 86 | 0.81 (0.70–0.92) |
| Kamphues, 2010 | FIB-4 | 2.8 | 44 | 87 | 88 | 42 | 0.66 (NA) |
| Pissaia, 2009 | FIB-4 | 3.25 | 31 | 94 | 67 | 77 | 0.78 (NA) |
| Segovia, 2008 | FIB-4 | 4.09 | 80 | 60 | 25 | 94 | NA |
Legend: TE: transient elastography, APRI: AST-to-platelet ratio index, FIB-4: Fibrosis score 4; NA, not available.