Table 3. Diagnostic accuracy of non-invasive tests to predict fibrosis F2-4 in individual studies included in the meta-analysis.

Author, Year	Test	Cut-off	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC (95% CI)
Della-Guardia, 2017	TE	12.3 kPa	43	91	72	76	0.78 (0.71–0.85)
Crespo, 2016	TE	6.8 kPa	73	71	57	83	0.76 (0.64–0.88)
Mikołajczyk-Korniak, 2016[38]	TE	4.7 kPa	93	57	90	66	0.746 (0.53–0.95)
Lutz, 2016	TE	8.35 kPa	84.6	91.4			0.89+/-0.057
Barrault, 2013	TE	7 kPa	88.2	67.9	62.5	90.5	0.83 (0.71–0.95)
Goldsmith, 2013	TE	9.3 kPa	90	81	75	93	0.93 (NA)
Crespo, 2012	TE	8.4 kPa	82	80	76	86	0.87 (NA)
Sebagh, 2012	TE	7.9 kPa	62.5	66.7	45	80	NA
Beckebaum, 2010	TE	7.3 kPa	73	100	100	52	0.86
Corradi, 2009	TE	10.1 kPa	94	89	81	94	0.94 (0.85–0.99)
Harada, 2008	TE	9.9 kPa	90	91	86	94	0.92 (NA)
Rigamonti, 2008	TE	7.9 kPa	81	76	65	88	0.85 (0.76–0.92)
Carrion, 2006	TE	8.5 kPa	90	81	79	92	0.90 (NA)
D’Souza, 2016	APRI	0.45	67	79	67	79	0.74 (0.57–0.91)
Crespo, 2016	APRI	1.36	69	87	75	83	0.83 (0.73–0.94)
Pinto, 2014	APRI	0.4	83	58	31	94	0.74 (0.54–0.95)
Kamphues, 2010	APRI	0.4845	70	63	80	80	0.68 (NA)
Carrion, 2010	APRI	-	-	-	-	-	0.50
Pissaia, 2009	APRI	0.5	81	80	62	91	0.87 (NA)
Corradi, 2010	APRI	1.3	67	74	55	82	0.82 (0.64–0.99)
Harada, 2008	APRI	0.84	73	91	63	76	0.70 (NA)
Toniutto, 2007	APRI	1.4	76	77	46	93	0.80 (NA)
Crespo, 2016	FIB-4	3.23	77	80	69	86	0.81 (0.70–0.92)
Kamphues, 2010	FIB-4	2.8	44	87	88	42	0.66 (NA)
Pissaia, 2009	FIB-4	3.25	31	94	67	77	0.78 (NA)
Segovia, 2008	FIB-4	4.09	80	60	25	94	NA

Legend: TE: transient elastography, APRI: AST-to-platelet ratio index, FIB-4: Fibrosis score 4; NA, not available.