Table 3. Ezrin expression in relation to clinicopathological variables (n = 173). CRC = colorectal cancer.
| Variable | Ezrin low | Ezrin high | Significance (p) |
|---|---|---|---|
| n (%) | n (%) | ||
| Gender | 0.272 | ||
| Female | 60 (44) | 21 (55) | |
| Male | 75 (56) | 17 (45) | |
| Age | 0.130 | ||
| Under 70 years | 56 (41) | 10 (26) | |
| Over 70 years | 79 (58) | 28 (74) | |
| Postoperative stage | 0.634 | ||
| T3N0 | 113 (84) | 30 (79) | |
| T4aN0 | 13 (10) | 4 10) | |
| T4bN0 | 9 (7) | 4 (10) | |
| Tumor side | 0.141 | ||
| Right | 65 (48) | 24 (63) | |
| Left | 70 (52) | 14 (37) | |
| Tumor grade | 0.119 | ||
| G1 | 14 (10) | 5 (13) | |
| G2 | 94 (70) | 20 (53) | |
| G3 | 27 (20) | 13 (34) | |
| Histology | 0.099 | ||
| Conventional adenocarcinoma | 121 (90) | 30 (79) | |
| Mucinous adenocarcinoma | 14 (10) | 8 (21) | |
| Vascular invasion | 0.677 | ||
| Yes | 26 (19) | 6 (16) | |
| No | 100 (74) | 31 (82) | |
| NA | 9 (7) | 1 (3) | |
| Lymph node count | 1.000 | ||
| 12 or more examined | 108 (80) | 30 (79) | |
| Less than 12 examined | 27 (20) | 8 (21) | |
| Radicality of surgery | 0.568 | ||
| R0 | 127 (94) | 35 (92) | |
| R1 | 6 (4) | 2 (5) | |
| R2 | 1 (1) | 1 (3) | |
| Preoperative obstruction | 0.607 | ||
| Yes | 19 (14) | 7 (18) | |
| No | 116 (86) | 31 (82) | |
| Tumor perforation | 0.476 | ||
| Yes | 10 (7) | 5 (13) | |
| No | 124 (92) | 33 (87) | |
| NA* | 1 (1) | 0 (0) | |
| Adjuvant chemotherapy | 1.000 | ||
| Yes | 40 (30) | 11 (29) | |
| No | 95 (70) | 26 (68) | |
| NA* | 0 (0) | 1 (3) | |
| MSI status | 0.001 | ||
| MSS | 117 (87) | 19 (50) | |
| MSI | 18 (13) | 19 (50) | |
| BRAF status | 0.001 | ||
| BRAF WT | 121 (91) | 25 (66) | |
| BRAF mutated | 12 (9) | 13 (34) | |
| Disease-specific outcome | 0.038 | ||
| Alive without CRC | 93 (69) | 23 (61) | |
| Alive with CRC | 3 (2) | 0 (0) | |
| Dead of CRC | 8 (6) | 9 (24) | |
| Dead of other cancer | 16 (12) | 2 (5) | |
| Dead of other causes | 11 (8) | 4 (11) | |
| Dead cause unspecified | 4 (3) | 0 (0) |