Table 1.
Conserved methylation motifs in Campylobacter
| Recognition sequence | C. jejuni laboratory strains | C. jejuni human isolate | C. jejuni sheep isolate | C. coli | C. peloridis | C. subantarcticus | UPTC NCTC | Campylobacter spp. | ||
| 81–176 (18) | 11168 (18) | F38011 (19) | IA3902 (20) | BfR-CA-9557 (21) | (22) | LMB 24374 (22) | LMG 24377 (22) | 11845 (22) | RM16704 (22) | |
| RAATTY | + | + | + | + | + | + | + | + | + | + |
| GATC | − | − | − | − | + | + | + | + | + | − |
| TAAYN5TGC | + | + | − | + | +/− | − | − | − | − | − |
| CAAGAA | − | − | − | − | + | + | − | − | − | − |
| GCAAGG | + | +/− | +/− | + | − | − | − | − | − | − |
| GAGN5GT | − | + | − | +/− | − | − | − | − | − | − |
Methylation motifs were determined using SMRT sequencing. Ambiguous nucleotides are denoted using IUPAC ambiguity codes. +/− indicates that the motif contains one nucleotide difference between the two strains. Underlining indicates the methylated base. Only motifs found to be methylated in more than one strain are included here. Numbers in parentheses refer to citations.